WEL Substance Profile
CAS: 7440-02-0 | Notation: Inhalable fraction, carcinogen (IARC Group 1 for nickel compounds, Group 2B for metallic nickel)
Current WES
1
mg/m³
New WEL (Dec 2026)
0.01
mg/m³
Change
-99%
reduction
Nickel compounds are classified as Group 1 carcinogens by IARC, with sufficient evidence of causing lung and nasal sinus cancer in humans. Metallic nickel is classified as Group 2B, possibly carcinogenic. Nickel is also one of the most common causes of allergic contact dermatitis, affecting approximately 10 to 15 per cent of the general population. Inhalation of nickel dust and fume causes occupational asthma through both allergic and irritant mechanisms. Chronic exposure leads to chronic rhinitis, sinusitis, and anosmia. Acute inhalation of high concentrations of nickel carbonyl, a volatile nickel compound formed during certain industrial processes, can cause fatal pulmonary oedema. Kidney toxicity has been documented in workers with chronic nickel exposure. The 99 per cent reduction in the exposure limit reflects growing evidence that health effects occur at much lower concentrations than previously recognised.
Personal air sampling using a calibrated pump at 2 L/min with an IOM inhalable sampler and mixed cellulose ester filter. Analysis by ICP-MS or ICP-OES after acid digestion. The extremely low WEL of 0.01 mg/m³ requires analytical methods with detection limits below 0.001 mg per sample — confirm with the laboratory that their method achieves adequate sensitivity.
EHS Atlas tracks nickel monitoring data against the incoming 0.01 mg/m³ WEL and automates health surveillance scheduling for welding and plating operations.
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